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Article

Dengue Virus Evolution under a Host-Targeted Antiviral.

Journal of virology - 1 May 2015

Plummer Emily, Buck Michael D, Sanchez Marisa, Greenbaum Jason A, Turner Julia, Grewal Rajvir, Klose Brennan, Sampath Aruna, Warfield Kelly L, Peters Bjoern, Ramstedt Urban, Shresta Sujan

Abstract excerpt

UNLABELLED: The host-targeted antiviral drug UV-4B reduces viral replication and promotes survival in a mouse model of experimental dengue virus (DENV) infection. UV-4B is an iminosugar that inhibits the α-glucosidase family of enzymes and subsequently the folding of glycosylated proteins, both viral and host. Here, we utilized next-generation sequencing to investigate evolution of a flavivirus under selective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25762732
DOI: 10.1128/JVI.00028-15
PMCID: PMC4442503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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