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Article

Analysis of Dengue Virus Genetic Diversity during Human and Mosquito Infection Reveals Genetic Constraints.

PLoS neglected tropical diseases - 1 Jan 2015

Sessions October M, Wilm Andreas, Kamaraj Uma Sangumathi, Choy Milly M, Chow Angelia, Chong Yuwen, Ong Xin Mei, Nagarajan Niranjan, Cook Alex R, Ooi Eng Eong

Abstract excerpt

Dengue viruses (DENV) cause debilitating and potentially life-threatening acute disease throughout the tropical world. While drug development efforts are underway, there are concerns that resistant strains will emerge rapidly. Indeed, antiviral drugs that target even conserved regions in other RNA viruses lose efficacy over time as the virus mutates. Here, we sought to determine if there are regions in the DENV...

Topics

Animals
Conserved Sequence
Culicidae
Dengue
Dengue Virus
Female
Genetic Variation
Genotype
High-Throughput Nucleotide Sequencing
Humans
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 26327586
DOI: 10.1371/journal.pntd.0004044
PMCID: PMC4556638

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