Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patterns of intra- and interhost nonsynonymous variation reveal strong purifying selection in dengue virus.

Journal of virology - 1 Oct 2003

Holmes Edward C

Abstract excerpt

Considerable uncertainty surrounds the evolutionary rates of and selection pressures acting on arthropod-borne RNA viruses (arboviruses). In particular, it is unclear why arboviruses such as dengue virus show substantial genetic variation within individual humans and mosquitoes yet low long-term rates of amino acid substitution. To address this question, I compared patterns of nonsynonymous variation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dengue Virus
Share to Evolution and Genetic Dynamics
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insect symbiosis and bacterial influences

Share to Mosquito-borne diseases and control

Share to Mutation

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 14512579
DOI: 10.1128/jvi.77.20.11296-11298.2003
PMCID: PMC224983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterns of intra- and interhost nonsynonymous variation reveal strong purifying selection in dengue virus.PMID 14512579Read ↗

Intrahost Genetic Diversity of Dengue Virus in Human Hosts and Mosquito Vectors under Natural Conditions Which Impact Replicative Fitness In Vitro.Semantic proximity Read ↗

Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes.Semantic proximity Read ↗

Tracking Dengue Virus Intra-host Genetic Diversity during Human-to-Mosquito Transmission.Semantic proximity Read ↗

Evolutionary dynamics of dengue virus populations within the mosquito vector.Semantic proximity Read ↗

Analysis of Dengue Virus Genetic Diversity during Human and Mosquito Infection Reveals Genetic Constraints.Semantic proximity Read ↗

Nucleotide substitutions in dengue virus serotypes from Asian and American countries: insights into intracodon recombination and purifying selection.Semantic proximity Read ↗

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells.Semantic proximity Read ↗

Dengue Virus Serotype 2 Intrahost Diversity in Patients with Different Clinical Outcomes.Semantic proximity Read ↗

Effects of Arbovirus Multi-Host Life Cycles on Dinucleotide and Codon Usage PatternsSemantic proximity Read ↗

Inter- and intra-host viral diversity in a large seasonal DENV2 outbreak.Semantic proximity Read ↗

Linking influenza virus evolution within and between human hostsSemantic proximity Read ↗

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young childrenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.