Article
Dengue virus RNA structure specialization facilitates host adaptation.
PLoS pathogens - 1 Jan 2015
Villordo Sergio M, Filomatori Claudia V, Sánchez-Vargas Irma, Blair Carol D, Gamarnik Andrea V
Abstract excerpt
Many viral pathogens cycle between humans and insects. These viruses must have evolved strategies for rapid adaptation to different host environments. However, the mechanistic basis for the adaptation process remains poorly understood. To study the mosquito-human adaptation cycle, we examined changes in RNA structures of the dengue virus genome during host adaptation. Deep sequencing and RNA structure analysis,...
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