Article
C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations.
Blood - 16 Dec 2010
Pulikkan John A, Peramangalam Philomina S, Dengler Viola, Ho Phoenix A, Preudhomme Claude, Meshinchi Soheil, Christopeit Maximilian, Nibourel Oliver, Müller-Tidow Carsten, Bohlander Stefan K, Tenen Daniel G, Behre Gerhard
Abstract excerpt
The transcription factor, CCAAT enhancer binding protein alpha (C/EBPα), is crucial for granulopoiesis and is deregulated by various mechanisms in acute myeloid leukemia (AML). Mutations in the CEBPA gene are reported in 10% of human patients with AML. Even though the C/EBPα mutants are known to display distinct biologic function during leukemogenesis, the molecular basis for this subtype of AML remains elusive....
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