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Article

Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation.

Drug metabolism and pharmacokinetics - 1 Feb 2015

Saito Takahiro, Honda Masashi, Takahashi Masamitsu, Tsukada Chiharu, Ito Miyabi, Katono Yuki, Hosono Hiroki, Saigusa Daisuke, Suzuki Naoto, Tomioka Yoshihisa, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension. In this study, we evaluated the in vitro...

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PMID: 25760539
DOI: 10.1016/j.dmpk.2014.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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