Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human CYP1A1 variants lead to differential eicosapentaenoic acid metabolite patterns.

Biochemical and biophysical research communications - 28 Oct 2005

Schwarz Dieter, Kisselev Pyotr, Chernogolov Alexey, Schunck Wolf-Hagen, Roots Ivar

Abstract excerpt

To answer the question whether the most common allelic variants of human CYP1A1, namely CYP1A1.1 (wild type), CYP1A1.2 (Ile462Val), and CYP1A1.4 (Thr461Asn), differ in their catalytic activity towards eicosapentaenoic acid (EPA), in vitro enzymatic assays were performed in reconstituted CYP1A1 systems. All CYP1A1 variants catalyzed EPA epoxygenation and hydroxylation to 17(R),18(S)-epoxyeicosatetraenoic acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arachidonic Acids

Share to Cytochrome P-450 CYP1A1

Share to Eicosapentaenoic Acid

Share to Kinetics

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 16153604
DOI: 10.1016/j.bbrc.2005.08.172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human CYP1A1 variants lead to differential eicosapentaenoic acid metabolite patterns.PMID 16153604Read ↗

Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F).Semantic proximity Read ↗

Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation.Semantic proximity Read ↗

Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical ImplicationsSemantic proximity Read ↗

Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity.Semantic proximity Read ↗

Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G.Semantic proximity Read ↗

CYP2J2 - regulation, function and polymorphism.Semantic proximity Read ↗

Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases.Semantic proximity Read ↗

Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation.Semantic proximity Read ↗

Human CYP1A1 allelic variants: baculovirus expression and purification, hydrodynamic, spectral, and catalytical properties and their potency in the formation of all-trans-retinoic acid.Semantic proximity Read ↗

Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).Semantic proximity Read ↗

Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation.Semantic proximity Read ↗

Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.