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Article

Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F).

International journal of molecular sciences - 28 Apr 2023

Lee Yoo-Bin, Kim Vitchan, Lee Sung-Gyu, Lee Gyu-Hyeong, Kim Changmin, Jeong Eunseo, Kim Donghak

Abstract excerpt

The human cytochrome P450 2C8 is responsible for the metabolism of various clinical drugs as well as endogenous fatty acids. Allelic variations can significantly influence the metabolic outcomes. In this study, we characterize the functional effects of four nonsynonymous single nucleotide polymorphisms *15, *16, *17, and *18 alleles recently identified in cytochrome P450 2C8. The recombinant allelic variant...

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Identifiers

PMID: 37175734
DOI: 10.3390/ijms24098032
PMCID: PMC10178350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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