Article
Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
Prostaglandins, leukotrienes, and essential fatty acids - 1 Apr 2018
Kim Woo-Young, Lee Su-Jun, Min Jungki, Oh Kyung-Suk, Kim Dong-Hyun, Kim Heui-Soo, Shin Jae-Gook
Abstract excerpt
CYP4F2 is an enzyme involved in the formation of 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid and metabolizes vitamin K into an inactive form. Our objectives were to identify new CYP4F2 genetic variants and to characterize the functional consequences of the conversion of arachidonic acid into 20-HETE. We used direct DNA sequencing to identify a total of 20 single-nucleotide polymorphisms (SNPs)...
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