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Article

A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2008

Sugimoto Ken, Akasaka Hiroshi, Katsuya Tomohiro, Node Koichi, Fujisawa Tomomi, Shimaoka Izumi, Yasuda Osamu, Ohishi Mitsuru, Ogihara Toshio, Shimamoto Kazuaki, Rakugi Hiromi

Abstract excerpt

CYP4A11 oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite with renovascular and tubular function in humans. A previous study demonstrated a significant association between the CYP4A11 gene polymorphism and hypertension; however, the precise mechanism of the association has not been clarified. To assess the involvement of CYP4A11 in the pathogenesis of hypertension, we sought to identify a...

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PMID: 18936345
DOI: 10.1161/HYPERTENSIONAHA.108.114082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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