Article
A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.
Hypertension (Dallas, Tex. : 1979) - 1 May 2008
Ward Natalie C, Tsai I-Jung, Barden Anne, van Bockxmeer Frank M, Puddey Ian B, Hodgson Jonathan M, Croft Kevin D
Abstract excerpt
Arachidonic acid is a major fatty acid that can be metabolized by the cytochrome P450 enzyme to a number of bioactive eicosanoids. A major metabolite of this oxidation is 20-hydroxyeicosatetraenoic acid, which acts as a potent vasoconstrictor. However, in the kidney, its vasoconstrictor actions can be offset by its natriuretic properties. A guanine-to-adenine polymorphism in the CYP4F2 gene was associated with a...
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