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Article

Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G.

Drug metabolism and pharmacokinetics - 1 Dec 2016

Han Songhee, Cha Gun-Su, Chun Young-Jin, Lee Chang Hoon, Kim Donghak, Yun Chul-Ho

Abstract excerpt

Human CYP4A11 is the major ω-hydroxylase of fatty acids in the liver and kidneys. It produces 20-hydroxyeicosatetraenoic acid as well as hydroxylates fatty acids. In this study, we investigated the biochemical properties of three alleles of CYP4A11: W126R, K276T, and S353G. Site-directed mutagenesis of the wild type CYP4A11 was performed, to construct the W126R, K276T, and S353G variant clones. The CYP4A11 wild...

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PMID: 27793475
DOI: 10.1016/j.dmpk.2016.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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