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Article

Multiplex Genome Engineering Using CRISPR/Cas Systems

4 Jan 2013

Abstract excerpt

Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We engineered two different type II CRISPR/Cas systems and demonstrate that Cas9 nucleases can be directed by short RNAs...

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PMID: 23287718
DOI: 10.1126/science.1231143

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