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Article

Introduction of the hybcell-based compact sequencing technology and comparison to state-of-the-art methodologies for KRAS mutation detection.

BioTechniques - 1 Mar 2015

Zopf Agnes, Raim Roman, Danzer Martin, Niklas Norbert, Spilka Rita, Pröll Johannes, Gabriel Christian, Nechansky Andreas, Roucka Markus

Abstract excerpt

The detection of KRAS mutations in codons 12 and 13 is critical for anti-EGFR therapy strategies; however, only those methodologies with high sensitivity, specificity, and accuracy as well as the best cost and turnaround balance are suitable for routine daily testing. Here we compared the perform...

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Source

Identifiers

PMID: 25757545
DOI: 10.2144/000114264

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25757545-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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