Article
Non-invasive sensitive detection of KRAS and BRAF mutation in circulating tumor cells of colorectal cancer patients.
Molecular oncology - 1 Apr 2015
Mohamed Suhaimi Nur-Afidah, Foong Yu Miin, Lee Daniel Yoke San, Phyo Wai Min, Cima Igor, Lee Esther Xing Wei, Goh Wei Lin, Lim Wei-Yen, Chia Kee Seng, Kong Say Li, Gong Min, Lim Bing, Hillmer Axel M, Koh Poh Koon, Ying Jackie Y, Tan Min-Han
Abstract excerpt
Characterization of genetic alterations in tumor biopsies serves as useful biomarkers in prognosis and treatment management. Circulating tumor cells (CTCs) obtained non-invasively from peripheral blood could serve as a tumor proxy. Using a label-free CTC enrichment strategy that we have established, we aimed to develop sensitive assays for qualitative assessment of tumor genotype in patients. Blood consecutively...
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