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Article

A PNA-mediated clamping PCR for routine detection of KRAS mutations in colorectal carcinoma.

The International journal of biological markers - 24 Mar 2014

Messa Francesca, Tonissi Federica, Millo Enrico, Bracco Enrico, Ungari Silvana, Lattanzio Laura, Merlano Marco, Damonte Gianluca, Lo Nigro Cristiana

Abstract excerpt

The detection of somatic mutations in a tumor represents a valuable tool for tumor characterization and provides the clinicians with information for setting up the most appropriate therapy. KRAS mutations in codons 12 and 13 are important biomarkers routinely analyzed in the clinic for the management of anti-EGFR treatment in colorectal carcinoma (CRC). Here we report a sensitive and inexpensive assay for KRAS...

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Source

Identifiers

PMID: 24242294
DOI: 10.5301/jbm.5000052

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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