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Article

Increased detection rates of EGFR and KRAS mutations in NSCLC specimens with low tumour cell content by 454 deep sequencing.

Virchows Archiv : an international journal of pathology - 1 Apr 2013

Moskalev Evgeny A, Stöhr Robert, Rieker Ralf, Hebele Simone, Fuchs Florian, Sirbu Horia, Mastitsky Sergey E, Boltze Carsten, König Helmut, Agaimy Abbas, Hartmann Arndt, Haller Florian

Abstract excerpt

Detection of activating EGFR mutations in NSCLC is the prerequisite for individualised therapy with receptor tyrosine kinase inhibitors (TKI). In contrast, mutant downstream effector KRAS is associated with TKI resistance. Accordingly, EGFR mutation status is routinely examined in NSCLC specimens, but the employed methods may have a dramatic impact on the interpretation of results and, consequently, therapeutic...

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Source

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Identifiers

PMID: 23468066
DOI: 10.1007/s00428-013-1376-6
PMCID: PMC3624006

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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