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Detection of Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma: Comparing Cobas 4800 EGFR Assay With Sanger Bidirectional Sequencing.

Clinical lung cancer - 1 Sept 2016

Ardakani Nima Mesbah, Giardina Tindaro, Grieu-Iacopetta Fabienne, Tesfai Yordanos, Carrello Amerigo, Taylor Jeremy, Robinson Cleo, Spagnolo Dominic, Amanuel Benhur

Abstract excerpt

INTRODUCTION: Accurate detection of epidermal growth factor receptor (EGFR) mutations has a crucial role in the current treatment of patients with lung adenocarcinoma, and identification of clinically relevant mutations would qualify patients for treatment with tyrosine kinase inhibitors. Historically, Sanger sequencing has been used as the reference standard assay for EGFR mutational analysis; however, Cobas...

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PMID: 26961433
DOI: 10.1016/j.cllc.2016.02.002

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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