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Article

Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.

Obesity (Silver Spring, Md.) - 1 Apr 2015

Ralston Jessica C, Matravadia Sarthak, Gaudio Nicholas, Holloway Graham P, Mutch David M

Abstract excerpt

OBJECTIVE: Polyunsaturated fatty acids (PUFAs) regulate fatty acid desaturase (FADS1, FADS2) expression in the liver; however, it is unknown whether PUFAs regulate FADS in adipocytes. This is important to study considering reports that link altered desaturase activity with adipose tissue PUFA profiles, body weight, and whole-body glucose homeostasis. Therefore, the present study aimed to determine the direct...

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Share to 3T3-L1 Cells
Share to Adipocytes
Share to Arachidonic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Delta-5 Fatty Acid Desaturase

Share to Docosahexaenoic Acids

Share to Fatty Acid Desaturases

Share to Fatty Acids, Unsaturated

Share to Gene Expression Regulation, Enzymologic

Source

Open in PubMed Open full text

Identifiers

PMID: 25755223
DOI: 10.1002/oby.21035
PMCID: PMC4942280

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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