Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.

International journal of obesity (2005) - 1 Aug 2019

Klingel Shannon L, Valsesia Armand, Astrup Arne, Kunesova Marie, Saris Wim H M, Langin Dominique, Viguerie Nathalie, Mutch David M

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 genes are associated with changes in serum and tissue polyunsaturated fatty acid (PUFA) content. PUFA regulate inflammatory signaling pathways in adipose tissue; however, the effect of SNPs in FADS1/FADS2 on adipose tissue inflammation is equivocal. The present study examined if SNPs in FADS1/FADS2 modify human subcutaneous adipose tissue (SAT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Delta-5 Fatty Acid Desaturase
Share to Fatty Acid Desaturases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids

Share to Immune System

Share to Linear Models

Share to Lipid Metabolism

Share to Multivariate Analysis

Share to Subcutaneous Fat

Source

Identifiers

PMID: 30082751
DOI: 10.1038/s41366-018-0169-z

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.PMID 30082751Read ↗

FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.Semantic proximity Read ↗

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.Semantic proximity Read ↗

Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.Semantic proximity Read ↗

FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on HealthSemantic proximity Read ↗

Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.Semantic proximity Read ↗

Influence of Fatty Acid Desaturase Enzyme-1 Gene (FADS-1) Polymorphism on Serum Polyunsaturated Fatty Acids Levels, Desaturase Enzymes, Lipid Profile, and Glycemic Control Parameters in Newly Diagnosed Diabetic Mellitus PatientsSemantic proximity Read ↗

FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.Semantic proximity Read ↗

FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.Semantic proximity Read ↗

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism.Semantic proximity Read ↗

FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.Semantic proximity Read ↗

The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults.Semantic proximity Read ↗

Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.