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Article

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.

Journal of the American Heart Association - 20 May 2016

Paramel Varghese Geena, Folkersen Lasse, Strawbridge Rona J, Halvorsen Bente, Yndestad Arne, Ranheim Trine, Krohg-Sørensen Kirsten, Skjelland Mona, Espevik Terje, Aukrust Pål, Lengquist Mariette, Hedin Ulf, Jansson Jan-Håkan, Fransén Karin, Hansson Göran K, Eriksson Per, Sirsjö Allan

Abstract excerpt

BACKGROUND: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)-1β and IL-18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood. METHODS AND RESULTS: Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27207962
DOI: 10.1161/JAHA.115.003031
PMCID: PMC4889178

Genes

NLRP3
CASP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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