Article
Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study.
Cardiovascular diabetology - 5 Dec 2011
Opstad Trine B, Pettersen Alf Å, Arnesen Harald, Seljeflot Ingebjørg
Abstract excerpt
BACKGROUND: Increased IL-18 serum levels have been associated with diabetes type 2, metabolic syndrome and the severity of atherosclerosis. The present study investigated the presence and influence of IL-18 genetic variants on gene- and protein expression in stable coronary artery disease (CAD) patients. METHODS: The +183 A/G (rs 5744292), -137 G/C (rs 187238) and -607 C/A (rs 1946518) polymorphisms were...
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