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Article

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue.

Aging cell - 1 Dec 2012

Rogers Nicole H, Landa Alejandro, Park Seongjoon, Smith Roy G

Abstract excerpt

Insulin sensitivity deteriorates with age, but mechanisms remain unclear. Age-related changes in the function of subcutaneous white adipose tissue (sWAT) are less characterized than those in visceral WAT. We hypothesized that metabolic alterations in sWAT, which in contrast to epididymal WAT, harbors a subpopulation of energy-dissipating UCP1+ brown adipocytes, promote age-dependent progression toward insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23020201
DOI: 10.1111/acel.12010
PMCID: PMC3839316

Genes

UCP1

Provenance

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