Back to search

Article

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure

2025-08-07

Abstract excerpt

Non-shivering thermogenesis by brown adipose tissue (BAT) is a promising target for anti-obesity therapies, making its regulatory mechanisms of significant translational interest. While cold-induced BAT thermogenesis (CIT) is well characterized, certain high-calorie diets can also activate BAT in the absence of cold, a process known as diet-induced thermogenesis (DIT). Despite its potential relevance to modern hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4a077df7-cb96-5b9b-b4c0-a4c508682939
DOI
10.1101/2025.08.05.666925
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold ExposureDOI 10.1101/2025.08.05.666925
Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic AvenuesSemantic proximity
Recent advances in our understanding of brown and beige adipose tissue: the good fat that keeps you healthySemantic proximity
Molecular and cellular regulation of thermogenic fatSemantic proximity
Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: a key to lean phenotype.Semantic proximity
Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenic response in subcutaneous adipose tissueSemantic proximity
Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health.Semantic proximity
Atrial natriuretic peptide orchestrates a coordinated physiological response to fuel non shivering thermogenesisSemantic proximity
Cold exposure drives weight gain and adiposity following chronic suppression of brown adipose tissueSemantic proximity
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.Semantic proximity
Towards a Better Understanding of Beige Adipocyte Plasticity.Semantic proximity
Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice.Semantic proximity
Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissueSemantic proximity
Select a neighboring publication to make it the new centre.