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Article

Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress.

Endocrinology - 1 May 2006

Ukropec Jozef, Anunciado Rea V P, Ravussin Yann, Kozak Leslie P

Abstract excerpt

We investigated the role of leptin in regulating energy metabolism through induction of uncoupling protein (UCP)-1-based brown fat thermogenesis by comparing phenotypes of energy balance in ob/ob and double-mutant ob/ob.Ucp1(-/-) mice. Measurements of adiposity and lean body mass (nuclear magnetic resonance), energy expenditure (indirect calorimetry), body weight, food intake, and core body temperature were...

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Source

Identifiers

PMID: 16469807
DOI: 10.1210/en.2005-1216

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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