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Article

A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism

1 Mar 2020

Abstract excerpt

UCP1-dependent thermogenesis is studied to define new strategies to ameliorate obesity and type 2 diabetes; however, animal models are mostly limited to germline mutations of UCP1, which can effect adaptive changes in UCP1-independent pathways. We develop an inducible mouse model for the sequential ablation of UCP1 + brown and brite/beige adipocytes in adult mice. We demonstrate that activated brown adipocytes...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 32160547
DOI: 10.1016/j.celrep.2020.02.055

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