Article

The metabolically protective energy expenditure increase of <i>Pik3r1</i> -related insulin resistance is not explained by Ucp1-mediated thermogenesis

2024-02-12

Abstract excerpt

Human SHORT syndrome is caused by dominant negative human PIK3R1 mutations that impair insulin-stimulated phosphoinositide 3-kinase (PI3K) activity. This produces severe insulin resistance (IR) and often reduced adiposity, commonly described as lipodystrophy. However unlike human primary lipodystrophies, SHORT syndrome does not feature fatty liver or dyslipidaemia. Pik3r1 Y657*/WT (Pik3r1 Y657* ) mice metaboli...

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Literature Corpus work: fe4a7613-615a-535a-8d13-fdf95493b5a2
DOI: 10.1101/2024.02.12.579851

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