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Article

Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid.

The international journal of neuropsychopharmacology - 3 Mar 2015

Li Hongliang, Wang Xueding, Zhou Yafang, Ni Guanzhong, Su Qibiao, Chen Ziyi, Chen Zhuojia, Li Jiali, Chen Xinmeng, Hou Xiangyu, Xie Wen, Xin Shuang, Zhou Liemin, Huang Min

Abstract excerpt

BACKGROUND: Weight gain is the most frequent adverse effect of valproic acid (VPA) treatment, resulting in poor compliance and many endocrine disturbances. Similarities in the weight change of monozygotic twins receiving VPA strongly suggests that genetic factors are involved in this effect. However, few studies have been conducted to identify the relevant genetic polymorphisms. Additionally, the causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25740917
DOI: 10.1093/ijnp/pyv021
PMCID: PMC4540110

Genes

LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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