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Article

Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain.

Progress in neuro-psychopharmacology & biological psychiatry - 7 Aug 2012

Brandl E J, Frydrychowicz C, Tiwari A K, Lett T A P, Kitzrow W, Büttner S, Ehrlich S, Meltzer H Y, Lieberman J A, Kennedy J L, Müller D J, Puls I

Abstract excerpt

BACKGROUND: Antipsychotic-induced weight gain (AIWG) is a serious side-effect of antipsychotic medication leading to metabolic syndrome and increased cardiovascular morbidity. Unfortunately, there are still no valid predictors to assess an individual's risk to gain weight. Previous studies have indicated an impact of genetic variation in the genes encoding leptin, LEP, and leptin receptor, LEPR, on AIWG, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22426215
DOI: 10.1016/j.pnpbp.2012.03.001

Genes

LEP
LEPR

Variants

rs7799039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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