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Article

Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight.

International journal of obesity (2005) - 1 Jun 2026

Wang Jiaqi, He Zihua, Shen Sisi, Yi Tong, Liu Shengyi, Yang Quan, Sander Josemir W, Zhou Dong, Sima Xiutian, Li Jinmei

Abstract excerpt

BACKGROUND: Obesity is common among people with epilepsy and is influenced by genetic susceptibility, lifestyle behaviours, and antiseizure medications (ASMs). How ASMs and lifestyle factors interact with genetic risk for obesity in epilepsy remains unclear. METHODS: This population-based cohort study analysed UK Biobank participants with epilepsy recruited between 2006 and 2010. Polygenic risk scores for body...

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PMID: 41942740
DOI: 10.1038/s41366-026-02069-4

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