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Article

Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI-SDS-A case series.

Pediatric obesity - 1 Jan 2020

Brandt Stephanie, von Schnurbein Julia, Lennerz Belinda, Kohlsdorf Katja, Vollbach Heike, Denzer Christian, Bode Harald, Hebebrand Johannes, Wabitsch Martin

Abstract excerpt

BACKGROUND: The clinical phenotype of patients with monogenic obesity due to mutations in the leptin receptor (LEPR) or melanocortin 4 receptor (MC4R) gene is characterized by impaired satiety and hyperphagia, leading to extreme, sometimes life-threatening weight gain. SUBJECTS/METHODS: In a case series, we analysed the effect of an off-label methylphenidate (MPH) use for 1 year as an individual treatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

Identifiers

PMID: 31670905
DOI: 10.1111/ijpo.12577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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