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Article

SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy.

Pediatric neurology - 1 Sept 2023

Zhu Jiahao, Lu Jieluan, Shen Xianhuan, He Yaodong, Xia Hanbing, Li Wenzhou, Guo Huijuan, Zhang Jianping, Fan Xiaomei

Abstract excerpt

BACKGROUND: Sodium channel genes, especially SCN1A, were reported to play an important role in the treatment outcomes of antiseizure medications. The aim of this study was to explore the association of SCN1A polymorphisms with efficacy and adverse drug reactions (ADRs) related to valproic acid (VPA) among Chinese children with epilepsy. METHODS: A total of 126 children with epilepsy treated with VPA for at least...

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Identifiers

PMID: 37451178
DOI: 10.1016/j.pediatrneurol.2023.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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