Article
Association between the -2548G/A polymorphism of the leptin gene and antipsychotic-induced weight gain: Analysis of the CATIE sample and meta-analysis.
Progress in neuro-psychopharmacology & biological psychiatry - 30 Aug 2020
Yoshida Kazunari, Maciukiewicz Malgorzata, Zai Clement C, Gonçalves Vanessa F, Brandl Eva J, Lieberman Jeffrey A, Meltzer Herbert Y, Tiwari Arun K, Kennedy James L, Müller Daniel J
Abstract excerpt
BACKGROUND: Antipsychotics, especially most of the second-generation antipsychotics, have a high risk for metabolic syndrome and antipsychotic-induced weight gain (AIWG). A promoter variant of the leptin (LEP) gene, -2548G/A (rs7799039), has been associated with AIWG in several studies. The aim of this study was to evaluate this association in the Clinical Antipsychotic Trials of Intervention Effectiveness...
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