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Article

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis.

PloS one - 1 Jan 2015

Höchst Bastian, Mikulec Julita, Baccega Tania, Metzger Christina, Welz Meike, Peusquens Julia, Tacke Frank, Knolle Percy, Kurts Christian, Diehl Linda, Ludwig-Portugall Isis

Abstract excerpt

CD11b+Gr1+ myeloid derived suppressor cells (MDSC) are known to be very potent suppressors of T cell immunity and can be further stratified into granulocytic MDSC and monocytic MDSC in mice based on expression of Ly6G or Ly6C, respectively. Here, using these markers and functional assays, we aimed to identify whether MDSC are induced during chronic inflammation leading to fibrosis in both kidney and liver and...

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Identifiers

PMID: 25738302
DOI: 10.1371/journal.pone.0119662
PMCID: PMC4349817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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