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Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets

18 Jun 2018

Abstract excerpt

Abstract Purpose: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of pathologically expanded myeloid cells with immunosuppressive activity. In human disease, three major MDSC subpopulations can be defined as monocytic (M-MDSC), granulocytic [polymorphonuclear-MDSC (PMN-MDSC)], and early stage (e-MDSC), which lacks myeloid lineage markers of the former two subsets. The purpose of this study was...

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PMID: 29914893
DOI: 10.1158/1078-0432.ccr-17-3726

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