Article
Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma.
Leukemia & lymphoma - 1 Dec 2014
Favaloro James, Liyadipitiya Tulita, Brown Ross, Yang Shihong, Suen Hayley, Woodland Narelle, Nassif Najah, Hart Derek, Fromm Phillip, Weatherburn Claire, Gibson John, Ho P Joy, Joshua Douglas
Abstract excerpt
Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that have been implicated as inhibitors of lymphopoiesis in patients with malignancies. They have a consensus phenotype of CD33+/CD11b+/HLA-DRlo/- and can be further divided into CD15 + granulocytic (G-MDSC) and CD14 + monocytic (M-MDSC) subsets. We characterized MDSCs in patients with multiple myeloma (MM) and found a significant...
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