Article

Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis

2024-04-01

Abstract excerpt

<h4>Background and aims</h4> Previously, we identified immune-suppressive circulating monocytic myeloid-derived suppressor cells (M-MDSC) in patients with cirrhosis and liver failure, which increased with disease severity and were associated with infections and mortality. Impaired immune responses and M-MDSC expansion were reversed by ex vivo polyinosinic:polycytidylic acid (poly(I:C)) treatment. Here, we aimed...

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Literature Corpus work: 67209ae5-368c-5ce3-9492-fbe99c7d53b9
DOI: 10.1101/2024.03.29.587228

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