Article
Comparative transcriptional and phenotypic peripheral blood analysis of kidney recipients under cyclosporin A or sirolimus monotherapy.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Dec 2010
Brouard S, Puig-Pey I, Lozano J-J, Pallier A, Braud C, Giral M, Guillet M, Londoño M C, Oppenheimer F, Campistol J M, Soulillou J-P, Sanchez-Fueyo A
Abstract excerpt
Due to its low level of nephrotoxicity and capacity to harness tolerogenic pathways, sirolimus (SRL) has been proposed as an alternative to calcineurin inhibitors in transplantation. The exact mechanisms underlying its unique immunosuppressive profile in humans, however, are still not well unders...
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