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Article

Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis.

Frontiers in immunology - 1 Jan 2021

Jiao Baihai, An Changlong, Tran Melanie, Du Hao, Wang Penghua, Zhou Dong, Wang Yanlin

Abstract excerpt

A hallmark of chronic kidney disease is renal fibrosis, which can result in progressive loss of kidney function. Currently, there is no effective therapy for renal fibrosis. Therefore, there is an urgent need to identify potential drug targets for renal fibrosis. In this study, we examined the effect of a selective STAT6 inhibitor, AS1517499, on myeloid fibroblast activation, macrophage polarization, and...

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Identifiers

PMID: 34512669
DOI: 10.3389/fimmu.2021.735014
PMCID: PMC8426438

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