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Article

Identification and characterization of mutations conferring resistance to D-amino acids in Bacillus subtilis.

Journal of bacteriology - 1 May 2015

Leiman Sara A, Richardson Charles, Foulston Lucy, Elsholz Alexander K W, First Eric A, Losick Richard

Abstract excerpt

UNLABELLED: Bacteria produce d-amino acids for incorporation into the peptidoglycan and certain nonribosomally produced peptides. However, D-amino acids are toxic if mischarged on tRNAs or misincorporated into protein. Common strains of the Gram-positive bacterium Bacillus subtilis are particularly sensitive to the growth-inhibitory effects of D-tyrosine due to the absence of D-aminoacyl-tRNA deacylase, an enzyme...

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Identifiers

PMID: 25733611
DOI: 10.1128/JB.00009-15
PMCID: PMC4403649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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