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Article

A tRNAModification-based strategy for Identifying amiNo acid Overproducers (AMINO).

Metabolic engineering - 1 Jul 2023

Guo Hao, Wang Ning, Ding Tingting, Zheng Bo, Guo Liwei, Huang Chaoyong, Zhang Wuyuan, Sun Lichao, Ma Xiaoyan, Huo Yi-Xin

Abstract excerpt

Amino acids have a multi-billion-dollar market with rising demand, prompting the development of high-performance microbial factories. However, a general screening strategy applicable to all proteinogenic and non-proteinogenic amino acids is still lacking. Modification of the critical structure of tRNA could decrease the aminoacylation level of tRNA catalyzed by aminoacyl-tRNA synthetases. Involved in a...

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PMID: 37149082
DOI: 10.1016/j.ymben.2023.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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