Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code.

Genome biology and evolution - 1 Mar 2014

Yu Allen Chi-Shing, Yim Aldrin Kay-Yuen, Mat Wai-Kin, Tong Amy Hin-Yan, Lok Si, Xue Hong, Tsui Stephen Kwok-Wing, Wong J Tze-Fei, Chan Ting-Fung

Abstract excerpt

The 20 canonical amino acids of the genetic code have been invariant over 3 billion years of biological evolution. Although various aminoacyl-tRNA synthetases can charge their cognate tRNAs with amino acid analogs, there has been no known displacement of any canonical amino acid from the code. Experimental departure from this universal protein alphabet comprising the canonical amino acids was first achieved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Amino Acyl-tRNA Synthetases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacillus subtilis

Share to Genetic Code

Share to RNA, Transfer

Share to Sequence Analysis, RNA

Share to Sigma Factor

Share to Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 24572018
DOI: 10.1093/gbe/evu044
PMCID: PMC3971595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code.PMID 24572018Read ↗

Genetic code mutations: the breaking of a three billion year invariance.Semantic proximity Read ↗

Simplification of the genetic code: restricted diversity of genetically encoded amino acids.Semantic proximity Read ↗

A tRNAModification-based strategy for Identifying amiNo acid Overproducers (AMINO).Semantic proximity Read ↗

Identification and characterization of mutations conferring resistance to D-amino acids in Bacillus subtilis.Semantic proximity Read ↗

Selection and characterization of Escherichia coli variants capable of growth on an otherwise toxic tryptophan analogue.Semantic proximity Read ↗

Comprehensive screening of amber suppressor tRNAs suitable for incorporation of non-natural amino acids in a cell-free translation system.Semantic proximity Read ↗

Site-specific incorporation of tryptophan analogues into recombinant proteins in bacterial cells.Semantic proximity Read ↗

Preventing escape and malfunction of recoded cells due to tRNA base changesSemantic proximity Read ↗

Three G.C base pairs required for the efficient aminoacylation of tRNATrp by tryptophanyl-tRNA synthetase from Bacillus subtilis.Semantic proximity Read ↗

Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code.Semantic proximity Read ↗

Cloning of the trp gene cluster from a tryptophan-hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence.Semantic proximity Read ↗

Continuous Hypermutation and Evolution of Noncanonical Amino Acid Synthases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.