Article
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.
Blood - 2 Apr 2020
van Zeventer Isabelle A, de Graaf Aniek O, Wouters Hanneke J C M, van der Reijden Bert A, van der Klauw Melanie M, de Witte Theo, Jonker Marianne A, Malcovati Luca, Jansen Joop H, Huls Gerwin
Abstract excerpt
Anemia is a major and currently poorly understood clinical manifestation of hematopoietic aging. Upon aging, hematopoietic clones harboring acquired leukemia-associated mutations expand and become detectable, now referred to as clonal hematopoiesis (CH). To investigate the relationship between CH and anemia of the elderly, we explored the landscape and dynamics of CH in older individuals with anemia. From the...
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