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Article

Glioma grade and mortality in relation to sequence variation in the mitochondrial genome.

Cancer genetics - 1 Jun 2025

Peeri Noah C, Teer Jamie K, Thompson Zachary J, Nabors L Burt, Brooks Marisa, Sologon Corneliu M, Williams Sion L, Egan Kathleen M

Abstract excerpt

PURPOSE: Glioma arises from glial cells and comprises ∼80 % of malignant adult brain tumors. The polymorphic mitochondrial genome plays a key role in maintaining redox homeostasis and generation of reactive oxygen species (ROS). ROS have a well-established role in glial tumors. We investigated associations between germline mtDNA variants and haplogroups with glioma grade and glioblastoma (GBM) survival. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40382795
DOI: 10.1016/j.cancergen.2025.05.001
PMCID: PMC12124938

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