Article
An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins.
Nature chemical biology - 1 Apr 2015
Tian Zhenhua, Sun Peng, Yan Yan, Wu Zhuhua, Zheng Qingfei, Zhou Shuaixiang, Zhang Hua, Yu Futao, Jia Xinying, Chen Dandan, Mándi Attila, Kurtán Tibor, Liu Wen
Abstract excerpt
The [4+2] cycloaddition remains one of the most intriguing transformations in synthetic and natural products chemistry. In nature, however, there are remarkably few enzymes known to have this activity. We herein report an unprecedented enzymatic [4+2] cyclization cascade that has a central role in the biosynthesis of pyrroindomycins, which are pentacyclic spirotetramate natural products. Beginning with a linear...
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