Article

Biosynthesis of pleuromutilin congeners using an <i>Aspergillus oryzae</i> expression platform

2022-12-04

Abstract excerpt

Pleuromutilin is an antibiotic diterpenoid made by Clitopilus passeckerianus and related fungi, and it is the progenitor of a growing class of semi-synthetic antibiotics used in veterinary and human medicine. To harness the biotechnological potential of this natural product class, a full understanding of its biosynthetic pathway is essential. Previously, a linear pathway for pleuromutilin biosynthesis was establi...

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Literature Corpus work: 34081163-8e52-55e2-b01e-d1122e1f9863
DOI: 10.1101/2022.12.03.518960

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