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Development of Inhibitors of the 2<i>C</i>-Methyl-<scp>d</scp>-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

25 Sept 2014

Abstract excerpt

Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2C-methyl-D-erythritol 4-phosphate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosphate (2), the universal precursors of isoprenoids, while humans exclusively utilize the alternative mevalonate...

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PMID: 25210872
DOI: 10.1021/jm5010978

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