Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin

Abstract excerpt

Diketopiperazines (DKPs) make up a large group of natural products with diverse structures and biological activities. Bicyclomycin is a broad-spectrum DKP antibiotic with unique structure and function: it contains a highly oxidized bicyclic [4.2.2] ring and is the only known selective inhibitor of the bacterial transcription termination factor, Rho. Here, we identify the biosynthetic gene cluster for bicyclomycin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Phylogenetic Studies
• Share to Microbial Natural Products and Biosynthesis
• Share to RNA and protein synthesis mechanisms