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Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery

19 Apr 2019

Abstract excerpt

Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have shown significant promise against antibiotic-resistant S. aureus and tuberculosis, as well as for the treatment of...

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PMID: 31010150
DOI: 10.3390/md17040232

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