Article
The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy.
Journal of bacteriology - 1 Mar 2010
Leistikow Rachel L, Morton Russell A, Bartek Iona L, Frimpong Isaac, Wagner Karleen, Voskuil Martin I
Abstract excerpt
Mycobacterium tuberculosis survives in latently infected individuals, likely in a nonreplicating or dormancy-like state. The M. tuberculosis DosR regulon is a genetic program induced by conditions that inhibit aerobic respiration and prevent bacillus replication. In this study, we used a mutant incapable of DosR regulon induction to investigate the contribution of this regulon to bacterial metabolism during...
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